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TLDR
The following paragraph summarises the whole blog post for those who don't want to go into the details
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Longevity isn't just about living longer—it’s about living healthier. NAD+, a crucial molecule for energy production and cellular repair, declines with age, contributing to fatigue, inflammation, and visible signs of ageing like wrinkles and loss of elasticity.
Nuchido TIME+ is a science-backed supplement designed to restore and optimise NAD+ levels naturally, supporting energy, vitality, and youthful skin. Unlike traditional NAD+ supplements, it uses a whole-system approach to reactivate your body’s own production pathways.
Clinically tested and vegan-friendly, it’s your gateway to enhanced healthspan and vitality.
What is Longevity?
The concept of longevity—living a longer, healthier life—has fascinated humans for centuries. But what does longevity really mean in today’s world of cutting-edge science? At its core, longevity is not just about extending lifespan but about improving healthspan, the portion of your life spent in good health. Modern science has revealed that cellular health and energy production are crucial to both.
One molecule that’s been generating excitement in longevity research is NAD+ (the oxidised form of nicotinamide adenine dinucleotide). Nicotinamide is a form of vitamin B3. This critical molecule plays a key role in energy production and cellular repair, making it a cornerstone of longevity science.
What Is NAD+ & Why Is It Important?
NAD+ is a coenzyme found in every cell of your body. It has two main roles:
Energy Production: NAD+ helps your cells convert food into usable energy by fueling mitochondria, the “powerhouses” of cells.
Cellular Repair: It activates sirtuins and other enzymes responsible for repairing DNA damage and reducing inflammation.
Unfortunately, NAD+ levels significantly decline as we age, halving every 20 years. This impairs the cell’s ability to generate energy and repair damage, ultimately leading to the physical signs and conditions associated with ageing.
Boosting NAD+ has become a key target for healthy ageing and those seeking to enhance their longevity and vitality.
How NAD+ Levels Relate to Longevity
Low NAD+ levels are associated with several hallmark signs of ageing, such as:
• Decreased mitochondrial function, leading to fatigue
• Increased cellular damage and inflammation
• Reduced ability to respond to stress at a molecular level
How does NAD+ Relate to Skin Health?
The cells in your skin experience cellular ageing the same way the rest of the body does. As cells lose their ability to repair and regenerate, damage accumulates, preventing normal cellular function. This ultimately causes the external physical signs of skin ageing, such as fine lines, wrinkles and loss of skin elasticity.
Currently, many topicals and treatments work to reverse these external signs of ageing. However, we need to shift our attention towards fixing and preventing internal damage, which impairs skin cell function.
Studies show that by targeting the hallmarks of ageing, the cellular ageing process can be slowed and reversed. NAD+ is one of the few molecules that is known to positively impact all the hallmarks of ageing.
By restoring NAD+ levels, studies suggest that we may be able to slow down—or even reverse—certain aspects of ageing. NAD+ supplementation has shown promise in improving energy, mental clarity, and overall cellular health.
However, the biology associated with NAD+ production is complex and involves many proteins, enzymes and pathways that interconnect and influence each other. So, there are limitations in targeting one specific area of the body’s ability to produce NAD+; it requires a multitargeted approach that considers the whole system.
Introducing Nuchido TIME+: A Science-Backed NAD+ Booster
After researching NAD+ supplementation we were the most impressed with the science behind Nuchido TIME+ and we are proud to partner with them in Holme Valley Skin Clinic's first official step towards what will become our Longevity Clinic.
Nuchido TIME+ was developed by a team of systems pharmacologists, specialists in understanding whole biological networks and identifying the most efficient ways to influence them. Nuchido TIME+ goes beyond a single target precursor like NR (nicotinamide riboside) or NMN (nicotinamide nono-nucleotide) and, instead, provides a whole system approach to improving the cell’s fundamental and youthful ability to make NAD+.
Nuchido TIME+ is a revolutionary supplement designed to restore and optimise NAD+ levels. Unlike traditional supplements, Nuchido TIME+ combines advanced science with natural ingredients to not only replenish NAD+ but also stimulate your body’s natural production.
What about Food Safety?
All Nuchido TIME+ ingredients are on The Food Supplements Directive list and have been assessed and approved by the European Food Safety Authority (EFSA)
Nuchido TIME+ is manufactured following GMP standards in an FDA-registered facility
Nuchido TIME+ complies with all UK and EU food supplement regulations
Nuchido TIME+ is vegan & gluten-free
Why choose Nuchido TIME+?
Clinically tested for safety and efficacy
Scientifically formulated to enhance cellular NAD+ production after only 7 days
Designed to support cellular energy, repair, and overall vitality
Reduces the biological ageing markers of glycation (as can be tested with Glycan Age Test Kits- contact us for more information)
Reverses biological age
Increases the amount of the longevity protein SIRT1 (Sirtuin 1)
Reduces inflammatory cytokines (small cell-signalling proteins) which indicates that the body is directing additional NAD+ production towards beneficial processes rather than towards inflammatory CD38, which also depletes NAD+ levels.
Why doesn't Nuchido TIME+ include NAD+ in the ingredients?
Unfortunately, you cannot ingest pure NAD+. NAD+ as a molecule is large and very unstable. This means it will not stay in its active form for very long before it reacts and changes its structure. The molecule is found in all living cells and this instability allows it to be involved in hundreds of metabolic processes. But in supplement form, it is broken down in the digestive system before it can even reach the bloodstream, let alone get to the cells that actually needed.
We recommend avoiding supplements containing NAD+ as an individual ingredient, it is likely a waste of money.
What about IV NAD+?
While intravenous (IV) NAD+ treatments manage to get the unstable NAD+ molecule directly into your blood, there is still the problem of moving the molecule from the bloodstream and into the cells, where it is needed. As NAD+ is a large molecule, to get past the cell membrane it requires a specific transporter channel protein and the only cells which have been shown to possess this specific channel are heart and brain cells.
Despite the popularity of these IV treatments, there is a distinct lack of clinical data to prove NAD+ IVs, injections or patches perform as advertised. It is also worth noting that putting such large quantities of NAD+ directly into your bloodstream , when it only has a few destinations where it can be used up, means your body must then work very hard to break it down and remove the waste. This is why people often report feeling nauseous or unwell when getting an NAD+ IV.
What about NR or NMN supplements?
Most powders and pills contain its precursors, nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN). These are the raw materials used to make NAD+ inside the cell. These are known as first-generation NAD+ boosters because they were the first products created to try and boost NAD+ levels. NR and NMN require certain transporter proteins to pass through a cell membrane, and not all cells have these. Also, when it comes to ageing, there is no evidence to suggest that our NAD+ is declining due to a lack of available precursor material for our cells to use.
While NR and NMN supplements can increase NAD+ levels, once the NAD+ is used up, nicotinamide (also known as NAM) is the waste product left behind and cannot be recycled by our older dysfunctioning cells. (In young healthy cells the NAM goes through the NAD+ Salvage Pathway and is converted back into NAD+ again.) A build-up of NAM can further disrupt cellular homeostasis and can cause methyl donor depletion. This is damaging because methyl donors are critically important for a multitude of cellular reactions.
Finally, because NR and NMN alone fail to address increased inflammation in the body, it is likely that the majority of the NAD+ increase will be consumed by CD38, further driving inflammation.
Unlike NR or NMN, the natural ingredients in Nuchido TIME+ have been selected to trigger your body to switch back on youthful cellular NAD+ production by reactivating a key enzyme called NAMPT (nicotinamide phosphoribosyltransferase) in the NAD+ Salvage Pathway.
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